Lightboxes are wonderful tools to show up some specific content and highlight it from our site: pictures, videos and content from other sites via iframes could be inside a lightbox.
Here you have a list of really nice responsive lightboxes plugins.
Free Responsive Lightbox Plugins
FancyBox
FancyBox is a well known and a veteran lightbox, however it has evolutioned to be updated to the challenges that the web presents to us nowadays. It has many features to be personalized, the main ones are:
It can display images, videos, PDF documents and iframes from Youtube, Vimeo or content from another site.
Look and feel can be customized
Change color overlay
It can be applied to one single image or to a collection converting it a gallery.
Facebook and Twitter share icons and functionality
Great tutorials and documentation to implement it
A WordPress plugin version
Magnific Popup
Magnific Popup aims to be a full solution for a lightbox and it has great features as:
Different types of content: images, Iframe, in line and Ajax content
Support for Retina
CSS3 animations
Zoom effect
Flare
Flare is a lightbox which supports touch gestures in tablets and mobiles. Besides supports video from social networks and self hosted. Do you like full screen mode for your pictures and video? This is the lightbox for you. Thumbnails supported.
Fresco
Fresco has similar features as the previous commented as Retina support, fullscreen mode, thumbnails, touch events, zoom, viewport resize and direction change. One feature to stress is the use of callback functions, only in the pro version.
Swipebox
Swipebox support gestures for screen devices, plus keyboard navigation on desktop. Transitions are made using CSS3 and fallback using jQuery in those browsers which do not support the new css rules. One nice feature of this plugin is that pictures can be filtered using Isotope and Swipebox can refresh depending dom variations.
flipLightBox
flipLightBox is a simple plugin with no css, its main features are the flip effect and the gallery with captions. Simple and effective.
Responsive eXtro Lightbox
Responsive eXtro Lightbox is a lightbox module for Joomla, a minimalist plugin for the mentioned CMS.
ARI Sexy Lightbox Lite
ARI Sexy Lightbox Lite is an alternative module for Joomla users, it is optimized for pictures and inline content. It supports 4 themes.
VisualLightBox
It is an application wizard which let you create galleries of images with a wide range of themes and when you have already uploaded the images, you can publish your gallery in a html, Joomla 1.5x or 2.5x or WordPress plugin. Ideal for people who does not want to write a single line of code or just a user who is in a hurry. It supports 31 languages.
Responsive Lightbox
This WordPress plugin has the capability to choose between two responsive lightboxes jQuery plugins (prettyPhoto and SwipeBox), and a control panel where you can personalize how you want the lightbox to behave regarding galleries, links and selectors.